MEDICATIONS: ACADEMY ADDRESSES WYDASE™ SHORTAGE

MEDICATIONS: ACADEMY ADDRESSES WYDASE™ SHORTAGE

May 1, 2001 — The Academy has recently sent members information on alternative anesthesia techniques in the wake of Wyeth-Ayerst's decision to stop making Wydase™, or hyaluronidase.

Last week, the Academy distributed to its members a booklet describing alternative anesthesia techniques and a videotape demonstrating sub-Tenon's anesthesia.

There is anecdotal evidence that in the absence of Wydase™, some patients are experiencing complications, such as post-operative strabismus and greater orbital swelling.

Many ophthalmologists have turned to compounding pharmacies to obtain hyaluronidase as an alternative to Wydase™. There are no uniform national standards for the production of drugs in compounding pharmacies; therefore, there is no definitive way to ensure the quality of a drug until it's used. The Academy has on its Web site a list of suggested questions to query compounding pharmacies.

Wydase's™ sole manufacturer, Wyeth-Ayerst, stopped making the drug in January 2001 due to regulatory compliance issues. The Academy attempted to work with Wyeth-Ayerst to find a solution, such as: finding another manufacturer to take over production, identifying manufacturers overseas that might wish to begin production in America, or providing Eye M.D.s with information about alternative anesthesia techniques to Wydase™, such as an increased use of topical anesthesia.

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