Медицинские услуги
© 2017-2021 Сайт «БЕЛМЕД.БАЙ», info@belmed.by
March 24, 2003 — Lipid-lowering therapy reduces strokes in patients with coronary heart disease, especially when total cholesterol is lowered to less than 230 mg/dL, according to an article in the March 24 issue of The Archives of Internal Medicine, a journal of the American Medical Association.
According to information in the article, although lowering blood cholesterol levels decreases the risk of coronary heart disease, whether it decreases the risk for stroke is unclear. Previous studies have shown that statins, a type of lipid-lowering medication, may be effective in reducing the incidence of stroke.
Philippe Lechat, M.D., Ph.D., of Centre Hospitalo-Universitaire Pitie-Salpetriere, Paris, France, and colleagues investigated the effects of lipid-lowering therapy on stroke prevention. The researchers performed a literature search from 1966 to 2001, and analyzed randomized trials of primary and secondary coronary heart disease prevention, testing statins, non-statin drugs, diet or other interventions that provided data on stroke incidence.
The researchers' analysis of 38 trials, including 83,161 patients showed a significant relative reduction (17 percent) in risk for strokes with lipid-lowering therapy (regardless of whether the therapy was for primary or secondary prevention, or what type of lipid-lowering therapy was used). The most substantial effects were obtained with statins, with a 26 percent relative reduction in the risk for stroke. Further analysis showed a significant correlation between the risk of stroke and total cholesterol levels.
"The results of this meta-analysis provide strong evidence in favor of the potential of LLTs (lipid-lowering therapies) to prevent stroke," write the authors. "Such preventive effect appears related to efficacy of LLT to lower blood cholesterol levels, explaining why the most convincing results were obtained with statins. Indeed, optimal prevention appears to be obtained when cholesterol level is lowered to less than 232 g/dL," the authors conclude.
Автоматический перевод на русский язык