Медицинские услуги
© 2017-2021 Сайт «БЕЛМЕД.БАЙ», info@belmed.by
LG Shamagian, AV Roman, JG Acuna, CP Gil, AV Lamela and JR Gonzalez-Juanatey
Heart. Published Online First: 10 October 2005. doi:10.1136/hrt.2005.064394
Background
A large number of studies have described that anaemia is associated with higher mortality in congestive heart failure (CHF) patients. Most of that studies were performed in CHF patients with depressed left ventricular systolic function (LVSF), underestimating the high prevalent group of patients with preserved LVSF.
Aim
To investigate the prevalence of anaemia and its influence on mortality among hospitalized CHF patients with preserved LVSF.
210 patients with preserved LVSF admitted to Cardiology Department of a tertiary hospital for CHF between 1/1/2000 and 31/12/2002 were analysed. Anaemic patients, who comprised 46% of the whole group, were older (75 vs. 72 years; p=0.036), spent longer in hospital (mean 13 vs. 11 days; p=0.007); had a greater prevalence of ischaemic heart disease (54% vs. 35%; p=0.009), left bundle branch block (12% vs. 4%; p=0.018) and kidney failure (56% vs. 34%; p=0.003); and had faster erythrocyte sedimentation rates (mean 50 vs. 26 mm/h; p<0.001) and a tendency to a lower serum cholesterol levels (mean 179 vs. 202 mg/dl; p=0.073) and smaller body mass index (mean 27 vs. 29 kg/m2; p=0.126). Kaplan-Meier analysis showed the anaemic group to have significantly poorer survival (p=0.0001), with a one-year survival rate of 72.2% as against 90.5% in the non anaemic group. Multivariate analysis showed anaemia to be the most powerful independent predictor of mortality, increasing the risk of death by a factor of 2.7 (p=0.003).
Conclusion
Anaemia is a very prevalent condition in hospitalized CHF patients with preserved LVSF and is associated in an independent way with higher mortality. Appropriately designed randomized studies are needed to determine whether the prevention and/or treatment of anaemia improve survival among these patients.